Vmbic3^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Vmbic3^C57BL/6J
• Name: ventral midbrain iron content 3; C57BL/6J
• MGI ID: MGI:3036618
• QTL: Vmbic3 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 76.29 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased ventral midbrain iron content compared to DBA/2J. (J:87918)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

This allele increases ventral midbrain iron content by 2-fold.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87918

15 BXD/Ty recombinant inbred (RI) strains were used to map QTLs associated with regional brain and liver iron content. (The BXD/Ty RI strains are derived from C57BL/6J and DBA/2J parental inbred strains.) Authors used P=0.01 as the cutoff point for statistical significance.

The following QTLs associated with ventral midbrain iron content (Vmbic) were identified:

Vmbic1 mapped to 81.6 cM on mouse Chromosome 1 near D1Mit425.

Vmbic2 mapped to 26 cM on mouse Chromosome 5 near D5Mit79.

Vmbic3 mapped to 65.2 cM on mouse Chromosome 7 near D7Mit371. Inheritance of C57BL/6J-derived alleles at Vmbic3 confers a 2-fold increase in VMB iron content compared to DBA/2J-derived alleles. This locus explains 56% of the phenotypic variance. Th (tyrosine hydroxylase) maps near Vmbic3 and may be a possible candidate gene.

Vmbic4 mapped to 15 cM on mouse Chromosome 7 near D7Mit246.

Vmbic5 mapped between 31 cM (D9Mit21) - 35 cM (D9Mit104) on mouse Chromosome 9. A potential candidate gene mapping near Vmbic5 is Drd2 (dopamine receptor 2).

Vmbic6 mapped to 44.8 cM on mouse Chromosome 11 near D11Mit245.

Vmbic7 mapped to 68 cM on mouse Chromosome 13 near D13Mit196. Vmbic7 is specific to female animals.

Vmbic8 mapped to 19 cM on mouse Chromosome 14 near D14Mit214. Inheritance of C57BL/6J-derived alleles at Vmbic3 confer a 25% increase in VMB iron content in male animals compared to DBA/2J-derived alleles.

Vmbic9 mapped to 22.8 cM on mouse Chromosome 17 near D17Mit11.

Vmbic10 mapped between 20 cM (D11Mit296) - 28 cM (D11Mit86) on mouse Chromosome 11. Candidate genes mapping near Vmbic10 include Gabra1, Gabrg2, and Adra1b.

The following QTLs associated with liver iron content (Lvic) were identified:

Lvic1 mapped between 78.7 cM (D2Mit412) and 95.5 cM (D2Mit51) on mouse Chromosome 2. Lvic1 is specific to female animals. A potential candidate gene mapping near Lvic1 is Ftl1-rs2 (ferritin light chain related sequence 2).

Lvic2 mapped to 49.2 cM on mouse Chromosome 3 near D3Mit12.

Lvic3 mapped between 64 cM (D6Mit301) - 74cM (D6Mit374) on mouse Chromosome 6. Lvic3 is specific to male animals.

Lvic4 mapped to 54 cM on mouse Chromosome 14 near D14Mit185. Lvic4 is specific to female animals.

Lvic5 mapped between 17.25 cM (DXMit68) - 20 cM (DXMit144) on mouse Chromosome X.

References

• Original: J:87918 Jones BC, et al., Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice. Nutr Neurosci. 2003 Dec;6(6):369-77
• All: 1 reference(s)