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Idd2NOD/ShiLt
QTL Variant Detail
Summary
QTL variant: Idd2NOD/ShiLt
Name: insulin dependent diabetes susceptibility 2; NOD/ShiLt
MGI ID: MGI:3036663
QTL: Idd2  Location: Chr9:99792386-99792481 bp  Genetic Position: Chr9, cM position of peak correlated region/allele: 52.24 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  NOD/ShiLt
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:30526

The percentage of circulating CD4+ T Cells in NOD/Smrf mice is 40-50% greater then NON/Lt mice, enabling the investigation of how this quantitative phenotype segregates in a BC1 population (NON/Lt x NOD/Smrf)F1 x NOD/Smrf and in an F2 population (NON/Lt x NOD/Smrf)F1 x (NON/Lt x NOD/Smrf)F1. Statistical analysis using t-tests showed a significant correlation of circulating CD4+ T cells with the mouse Chromosome 9 marker D9Mit12 in both male and female segregants. The gene or genetic region responsible for this phenotype is termed Tlf (T lymphocyte frequency) Importantly, the authors show a correlation of Tlf with diabetic incidence as expressed by NON/Lt and NOD/Smrf mice suggesting that Tlf may in fact be the mouse Chromosome 9 locus Idd2.

References
Original:  J:29464 Prochazka M, et al., Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocks. Diabetes. 1989 Nov;38(11):1446-55
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory