Sox3^tm1Rlb
Targeted Allele Detail

Summary

• Symbol: Sox3^tm1Rlb
• Name: SRY (sex determining region Y)-box 3; targeted mutation 1, Robin Lovell-Badge
• MGI ID: MGI:3036671
• Synonyms: Sox3^deltagfp
• Gene: Sox3 Location: ChrX:59934972-59937036 bp, - strand Genetic Position: ChrX, 33.66 cM, cytoband A7.3-B
• Alliance: Sox3^tm1Rlb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88507
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Other
• Mutation details: The endogenous coding region was replaced with a construct containing floxed Sox3 sequence followed by GFP and frt-flanked neo. The floxed Sox3 sequence was removed via cre-mediated recomibination in the germline, leaving GFP downstream of the endogenous promoter. Mutant XY embryos expressed GFP, but not Sox3, in a pattern consistent with that of endogenous Sox3 expression in wild-type mice. This allele was derived from Sox3^tm2Rlb (J:88507)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox3 Mutation: 7 strains or lines available

References

• Original: J:88507 Rizzoti K, et al., SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat Genet. 2004 Mar;36(3):247-55
• All: 7 reference(s)