Gipr^tm1Thor
Targeted Allele Detail

Summary

• Symbol: Gipr^tm1Thor
• Name: gastric inhibitory polypeptide receptor; targeted mutation 1, Bernard Thorens
• MGI ID: MGI:3036704
• Synonyms: Gipr^-
• Gene: Gipr Location: Chr7:18889986-18900052 bp, - strand Genetic Position: Chr7, 9.46 cM
• Alliance: Gipr^tm1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88159
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 6 were replaced with a neomycin cassette via homologous recombination. A functional assay indicated the inactivation of the encoded protein. (J:88159)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gipr Mutation: 30 strains or lines available

References

• Original: J:88159 Preitner F, et al., Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. J Clin Invest. 2004 Feb;113(4):635-45
• All: 16 reference(s)