Ccr10^tm1Cge
Targeted Allele Detail

Summary

• Symbol: Ccr10^tm1Cge
• Name: C-C motif chemokine receptor 10; targeted mutation 1, Craig Gerard
• MGI ID: MGI:3036706
• Synonyms: CCR10 -
• Gene: Ccr10 Location: Chr11:101063824-101066269 bp, - strand Genetic Position: Chr11, 64.34 cM
• Alliance: Ccr10^tm1Cge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69621
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The first ATG codon of the gene was mutated to an EcoRV site, with an enhanced GFP gene and a neomycin resistance cassette being inserted into the EcoRV site. Gene inactivation was confirmed by a lack of product from RT-PCR of Peyer's patch RNA. GFP expression was observed in B cells expressing IgA, and in other leukocyte subsets including neutrophils. (J:69621, J:140728)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccr10 Mutation: 13 strains or lines available

References

• Original: J:69621 Bhat MA, et al., Axon-glia interactions and the domain organization of myelinated axons requires neurexin iv/caspr/paranodin. Neuron. 2001 May;30(2):369-83
• All: 7 reference(s)