Ptafr^tm1Tksh
Targeted Allele Detail

Summary

• Symbol: Ptafr^tm1Tksh
• Name: platelet-activating factor receptor; targeted mutation 1, Takao Shimizu
• MGI ID: MGI:3036770
• Synonyms: pafr^-
• Gene: Ptafr Location: Chr4:132291378-132309994 bp, + strand Genetic Position: Chr4, 65.56 cM, cytoband D2.2
• Alliance: Ptafr^tm1Tksh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88505
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the open reading frame disrupting this gene. Northern analysis of RNA isolated from neutrophils from homozygotes demonstrated that no detectable transcript is produced from this allele. No antagonist binding was detectable in peritoneal macrophages or lung tissues from homozygotes. (J:88505)

Expression

In Mice Carrying this Mutation:

9 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ptafr Mutation: 22 strains or lines available

References

• Original: J:88505 Ishii S, et al., Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J Exp Med. 1998 Jun 1;187(11):1779-88
• All: 62 reference(s)