Elovl3^tm1Jaco
Targeted Allele Detail

Summary

• Symbol: Elovl3^tm1Jaco
• Name: ELOVL fatty acid elongase 3; targeted mutation 1, Anders Jacobsson
• MGI ID: MGI:3036781
• Gene: Elovl3 Location: Chr19:46120336-46124133 bp, + strand Genetic Position: Chr19, 38.75 cM
• Alliance: Elovl3^tm1Jaco page

Hair follicle, epidermis and sebaceous gland abnormalities Elovl3^tm1Jaco/Elovl3^tm1Jaco mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88477
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the transcription start and exons 1 and 2 of the genomic DNA with a neomycin cassette via homologous recombination. Northern blot analysis on brown adipose tissue, skin, and liver samples of homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:88477)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elovl3 Mutation: 23 strains or lines available

References

• Original: J:88477 Westerberg R, et al., Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem. 2004 Feb 13;279(7):5621-9
• All: 3 reference(s)