Idd9.3^C57BL/10SnJ
QTL Variant Detail

Summary

• QTL variant: Idd9.3^C57BL/10SnJ
• Name: insulin dependent diabetes susceptibility 9.3; C57BL/10SnJ
• MGI ID: MGI:3036809
• Synonyms: Idd9.3^C57BL/10
• QTL: Idd9.3 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: C57BL/10SnJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac. (J:63670)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:100305

Fine mapping of NOD.B10-Idd9.3 subcongenic lines refined the Idd9.3 QTL interval to a 1.2 Mb region on distal mouse Chromosome 4. The interval contains 15 genes, one of which is the candidate gene Tnfrsf9. (Authors refer to Tnfrsf9 as 4-1BB.) The refinedIdd9.3 region spans approximately 146.5 Mb to 147.7 Mb.

References

• Original: J:63670 Lyons PA, et al., The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137. Immunity. 2000 Jul;13(1):107-15
• All: 7 reference(s)