Idd12^NOD/ShiLt
QTL Variant Detail

Summary

• QTL variant: Idd12^NOD/ShiLt
• Name: insulin dependent diabetes susceptibility 12; NOD/ShiLt
• MGI ID: MGI:3036813
• QTL: Idd12 Location: unknown Genetic Position: Chr14, cM position of peak correlated region/allele: 20.81 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NOD/ShiLt

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to insulin dependent diabetes compared to C57BL/6 and SJL. (J:19245)

Notes

Homozygosity for NOD/Lt-derived alleles confers susceptibility to type 1 diabetes.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:19245

A diabetes susceptibility gene (Idd12) was indicated as mapping proximal to D14Mit45 on Chromosome 14 in 30 nondiabetic homozygous H2^g7 backcross female mice derived from a NOD/Lt x (C57BL/6J x NOD/Lt)F1 mating.

References

• Original: J:19245 Morahan G, et al., Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5898-902
• All: 1 reference(s)