Idd17^C57BL/10SnJ
QTL Variant Detail

Summary

• QTL variant: Idd17^C57BL/10SnJ
• Name: insulin dependent diabetes susceptibility 17; C57BL/10SnJ
• MGI ID: MGI:3036822
• QTL: Idd17 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: C57BL/10SnJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to insulin dependent diabetes compared to NOD. (J:42103)
• Inheritance: Not Specified

Notes

Idd17 interacts with Idd10 to promote disease resistance.

Homozygosity for C57BL/10SnJ-derived alleles at both Idd10 and Idd17 confers significantly increased resistance to type 1 diabetes.

References

• Original: J:42103 Podolin PL, et al., Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two gene mediating the Idd10 effect and eliminates the candidate Fcgr1. J Immunol. 1997 AUG 15;159(4):1835-1843
• All: 1 reference(s)