Idd19^PWK
QTL Variant Detail

Summary

• QTL variant: Idd19^PWK
• Name: insulin dependent diabetes susceptibility 19; PWK
• MGI ID: MGI:3036826
• QTL: Idd19 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: PWK

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to insulin dependent diabetes compared to NOD/Lt. (J:48505)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:48505

A genome wide scan for loci responsible for insulin-dependent diabetes was initiated in mice derived from a (NOD x PWK)F1 x NOD backcross. A susceptiblity allele from PWK was observed to segregate with markers on distal mouse Chromosome 6 between D6Mit21andD6Mit14. Various congenic strains were constructed to verify the position of Idd19 within a 9 cM region between D6Mit11 and D6Mit25.

References

• Original: J:48505 Melanitou E, et al., Evidence for the presence of insulin-dependent diabetes-associated alleles on the distal part of mouse chromosome 6. Genome Res. 1998 Jun;8(6):608-20
• All: 1 reference(s)