Srsf2^tm1.1Xdfu
Targeted Allele Detail

Summary

• Symbol: Srsf2^tm1.1Xdfu
• Name: serine and arginine-rich splicing factor 2; targeted mutation 1.1, Xiang-Dong Fu
• MGI ID: MGI:3036849
• Synonyms: SC35^-
• Gene: Srsf2 Location: Chr11:116740727-116743920 bp, - strand Genetic Position: Chr11, 81.49 cM
• Alliance: Srsf2^tm1.1Xdfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88432
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1 and 2 were deleted by cre-mediated recombination of flanking loxP sites. This resulted in germline deletion of the entire coding region of the gene. (J:88432, J:88668)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srsf2 Mutation: 11 strains or lines available

References

• Original: J:88432 Ding JH, et al., Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J. 2004 Feb 25;23(4):885-96
• All: 2 reference(s)