Idd5.2^C57BL/10SnJ
QTL Variant Detail

Summary

• QTL variant: Idd5.2^C57BL/10SnJ
• Name: insulin dependent diabetes susceptibility 5.2; C57BL/10SnJ
• MGI ID: MGI:3036879
• Synonyms: Idd5.2
• QTL: Idd5.2 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: C57BL/10SnJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac. (J:88667)

Notes

Candidate Genes

J:107559

Congenic mouse strains within the Idd5.2 (MGI: Idd5b) region of mouse Chromosome 1 were utilized to suggest that solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (Slc11a1) is a likely candidate for Idd5.2. Using RNAi (RNA interference) the authors showed that a knockdown of Slc11a1 (allele Nramp1) had a detectable effect on diabetes incidence conferred within the Idd5.2 region.

References

• Original: J:88667 Hill NJ, et al., NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes. 2000 Oct;49(10):1744-7
• All: 7 reference(s)