Ighm^tm1Fbb
Targeted Allele Detail

Summary

• Symbol: Ighm^tm1Fbb
• Name: immunoglobulin heavy constant mu; targeted mutation 1, Frank Brombacher
• MGI ID: MGI:3037070
• Synonyms: IgM^-
• Gene: Ighm Location: Chr12:113382446-113386350 bp, - strand Genetic Position: Chr12, 62.1 cM, cytoband F1-2
• Alliance: Ighm^tm1Fbb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57600
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A single loxP site remained in place of a genomic fragment encompassing Igh-6 exons mu1 through mu4 and a portion of the intergenic region between Igh-6 and Igh-5 after the incorporation and subsequent excision of a floxed neo-HSV cassette. The intergenic region contained regulatory cis-elements of the Igh-5 locus. IgM (Igh-6) was undetected by flow cytometric analysis whereas levels of soluble IgD (Igh-5) were increased relative to wild-type. (J:57600)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighm Mutation: 56 strains or lines available

References

• Original: J:57600 Lutz C, et al., IgD can largely substitute for loss of IgM function in B cells. Nature. 1998 Jun 25;393(6687):797-801
• All: 15 reference(s)