Prkca^tm1Jmk
Targeted Allele Detail

Summary

• Symbol: Prkca^tm1Jmk
• Name: protein kinase C, alpha; targeted mutation 1, Jeffery D Molkentin
• MGI ID: MGI:3037088
• Synonyms: Prkca^-
• Gene: Prkca Location: Chr11:107824213-108234754 bp, - strand Genetic Position: Chr11, 70.8 cM
• Alliance: Prkca^tm1Jmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88510
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination was used to replace the exon encoding the ATP-binding cassette with a neomycin resistance gene. A lack of protein expression was confirmed by Western blot analysis. (J:88510)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkca Mutation: 44 strains or lines available

References

• Original: J:88510 Braz JC, et al., PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med. 2004 Mar;10(3):248-54
• All: 30 reference(s)