Tia1^tm1Andp
Targeted Allele Detail

Summary

• Symbol: Tia1^tm1Andp
• Name: cytotoxic granule-associated RNA binding protein 1; targeted mutation 1, Paul Anderson
• MGI ID: MGI:3037091
• Synonyms: TIA-1-
• Gene: Tia1 Location: Chr6:86381201-86410387 bp, + strand Genetic Position: Chr6, 37.69 cM, cytoband D2
• Alliance: Tia1^tm1Andp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88770
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of parts of intron 3 and exon 4 of the genomic DNA with a neomycin cassette via homologous recombination. Southern blot analysis confirmed recombination and immunoprecipitation demonstrated that no detectable protein is produced from this allele. (J:88770)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tia1 Mutation: 68 strains or lines available

References

• Original: J:88770 Piecyk M, et al., TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J. 2000 Aug 1;19(15):4154-63
• All: 13 reference(s)