Tg(Myh6-Prkca)1Jmk
Transgene Detail

Summary

• Symbol: Tg(Myh6-Prkca)1Jmk
• Name: transgene insertion 1, Jeffery D Molkentin
• MGI ID: MGI:3037092
• Transgene: Tg(Myh6-Prkca)1Jmk Location: unknown
• Alliance: Tg(Myh6-Prkca)1Jmk page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Prkca)1Jmk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prkca (MGI:97595)

• Mutation details: Wild-type mouse Prkca cDNA was adjoined to 5.5 kb of murine Myh6 promoter to drive expression of Prkca in a cadriac-specific manner. Quantitative Western blotting revealed a five-fold increase of PRKCA in cardiac tissue. (J:88510)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:88510 Braz JC, et al., PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med. 2004 Mar;10(3):248-54
• All: 1 reference(s)