Pou2f2^tm1Lmc
Targeted Allele Detail

Summary

• Symbol: Pou2f2^tm1Lmc
• Name: POU domain, class 2, transcription factor 2; targeted mutation 1, Lynn M Corcoran
• MGI ID: MGI:3037094
• Synonyms: Oct2^deltaC
• Gene: Pou2f2 Location: Chr7:24790111-24879292 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Pou2f2^tm1Lmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88240
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a translational stop codon at the end of the POU homeodomain encoding exon by homologous recombination results a truncated protein. All sequences C-terminal to the DNA-binding domain are removed from proteins translated from this allele. Western blots demonstrated that this truncated protein is produced and stable in vitro. (J:88240)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou2f2 Mutation: 29 strains or lines available

References

• Original: J:88240 Corcoran LM, et al., All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain. J Immunol. 2004 Mar 1;172(5):2962-9
• All: 1 reference(s)