Moo1^BTBR
QTL Variant Detail

Summary

• QTL variant: Moo1^BTBR
• Name: modifier of obesity 1; BTBR
• MGI ID: MGI:3037108
• QTL: Moo1 Location: Chr2:65269746-65269934 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 38.54 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BTBR

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased 10-week body mass compared to C57BL/6. (J:87998)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87998

350 (BTBR x B6.Cg-Lep^ob)F2 animals were typed at 99 polymorphic loci to identify QTLs modifying obesity. BTBR.Cg-Lep^ob/Lep^ob animals are severely obese and exhibit significantly increased food intake compared to B6.Cg-Lep^ob/J animals.

A QTL named Mobe1 (modifier of obesity 1) mapped to 37 cM on mouse Chromosome 2 with peak linkage at D2Mit9 (LOD=9.48). BTBR-derived alleles confer increased 10-week body mass with semidominant inheritance and explains about 14% of the phenotypic variance. Mobe1 was fine-mapped using interval specific congenic strains (ISCS) to an interval flanked by D2Mit56 (41 cM) and D2Mit159 (47.1 cM). This region is syntenic to human Chromosome 2q24-32.

Mobe2 mapped to 37 cM on mouse Chromosome 13 with peak linkage atD13Mit66 (LOD=8.0). C57BL/6-derived alleles confer increased 10-week body mass with dominant inheritance and explains about 12.5% of the phenotypic variance.

Mobe3 and Mobe4 mapped to 65 cM on mouse Chromosome 5 (LOD=3.6) and to 34.4 cM on mouse Chromosome 17 (LOD=2.49), respectively. Mobe3 and Mobe4 showed suggestive linkage using interval mapping but the LOD scores improved when multiple interval mapping was employed.

References

• Original: J:87998 Stoehr JP, et al., Identification of major quantitative trait loci controlling body weight variation in ob/ob mice. Diabetes. 2004 Jan;53(1):245-9
• All: 1 reference(s)