Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:87998350 (BTBR x B6.Cg-Lepob)F2 animals were typed at 99 polymorphic loci to identify QTLs modifying obesity. BTBR.Cg-Lepob/Lepob animals are severely obese and exhibit significantly increased food intake compared to B6.Cg-Lepob/Lepob animals. A QTL named Mobe1 (modifier of obesity 1) mapped to 37 cM on mouse Chromosome 2 with peak linkage at D2Mit9 (LOD=9.48). BTBR-derived alleles confer increased 10-week body mass with semidominant inheritance and explains about 14% of the phenotypic variance. Mobe1 was fine-mapped using interval specific congenic strains (ISCS) to an interval flanked by D2Mit56 (41 cM) and D2Mit159 (47.1 cM). This region is syntenic to human Chromosome 2q24-32.Mobe2 mapped to 37 cM on mouse Chromosome 13 with peak linkage atD13Mit66 (LOD=8.0). C57BL/6-derived alleles confer increased 10-week body mass with dominant inheritance and explains about 12.5% of the phenotypic variance. Mobe3 and Mobe4 mapped to 65 cM on mouse Chromosome 5 (LOD=3.6) and to 34.4 cM on mouse Chromosome 17 (LOD=2.49), respectively. Mobe3 and Mobe4 showed suggestive linkage using interval mapping but the LOD scores improved when multiple interval mapping was employed. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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