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Moo2BTBR
QTL Variant Detail
Summary
QTL variant: Moo2BTBR
Name: modifier of obesity 2; BTBR
MGI ID: MGI:3037110
QTL: Moo2  Location: Chr13:67318411-67318559 bp  Genetic Position: Chr13, cM position of peak correlated region/allele: 34.54 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  BTBR
Variant
description
Allele Type:    QTL
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87998

350 (BTBR x B6.Cg-Lepob)F2 animals were typed at 99 polymorphic loci to identify QTLs modifying obesity. BTBR.Cg-Lepob/Lepob animals are severely obese and exhibit significantly increased food intake compared to B6.Cg-Lepob/Lepob animals.

A QTL named Mobe1 (modifier of obesity 1) mapped to 37 cM on mouse Chromosome 2 with peak linkage at D2Mit9 (LOD=9.48). BTBR-derived alleles confer increased 10-week body mass with semidominant inheritance and explains about 14% of the phenotypic variance. Mobe1 was fine-mapped using interval specific congenic strains (ISCS) to an interval flanked by D2Mit56 (41 cM) and D2Mit159 (47.1 cM). This region is syntenic to human Chromosome 2q24-32.

Mobe2 mapped to 37 cM on mouse Chromosome 13 with peak linkage atD13Mit66 (LOD=8.0). C57BL/6-derived alleles confer increased 10-week body mass with dominant inheritance and explains about 12.5% of the phenotypic variance.

Mobe3 and Mobe4 mapped to 65 cM on mouse Chromosome 5 (LOD=3.6) and to 34.4 cM on mouse Chromosome 17 (LOD=2.49), respectively. Mobe3 and Mobe4 showed suggestive linkage using interval mapping but the LOD scores improved when multiple interval mapping was employed.

References
Original:  J:87998 Stoehr JP, et al., Identification of major quantitative trait loci controlling body weight variation in ob/ob mice. Diabetes. 2004 Jan;53(1):245-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory