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Tbdr1LS
QTL Variant Detail
Summary
QTL variant: Tbdr1LS
Name: body temperature response to dietary restriction, QTL 1; LS
MGI ID: MGI:3037651
QTL: Tbdr1  Location: Chr9:52034478-52034599 bp  Genetic Position: Chr9, cM position of peak correlated region/allele: 28.62 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  LS
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:88523

22 LSxSS recombinant inbred (RI) strains were analyzed for loci associated with altered body temperature in response to dietary restriction. Decreased body temperature is a hallmark of dietary restriction, which is also associated with life extension. Dietary restricted animals were fed 60% the amount of food as ad libitum control animals. 72 markers at an average spacing of 20 cM were used in the genome scan.

A significant locus named Tbdr1 (body temperature response to dietary restriction, QTL 1) mapped to 29 cM on mouse Chromosome 9 with peak linkage at D9Mit4 (LOD=3.1). SS-derived alleles confer decreased body temperature at Tbdr1. This locus explains approximately 49% of the genetic variance. The 95% confidence interval of Tbdr1 spans from D9Mit228(26 cM) to D9Mit6 (31 cM). Nine candidate genes in this region show altered expressed in dietary restricted animals. These genes are H2afx, Hyou1 (Cab140), Apoa1, Apoa4, Zfp145 (Plzf), Drd2, Cyp19a1, Dnaja4, and Csk.

A suggestive locus mapped to 24 cM on mouse Chromosome 17 between D17Mit49 (23.2 cM) and D17Mit10 (24.5 cM) with LOD=1.5. This locus explains approximately 17% of the genetic variance with SS-derived alleles conferring decreased body temperature.

References
Original:  J:88523 Rikke BA, et al., Quantitative trait Loci specifying the response of body temperature to dietary restriction. J Gerontol A Biol Sci Med Sci. 2004 Feb;59(2):118-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory