Igh^tm5.1Cgn
Targeted Allele Detail

Summary

• Symbol: Igh^tm5.1Cgn
• Name: immunoglobulin heavy chain complex; targeted mutation 5.1, University of Cologne
• MGI ID: MGI:3037893
• Synonyms: DHLMP2A
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88472
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The floxed fragment encompassing the inserted Igh-V 186.2 promoter region and the stop cassette was excised from Igh^tm5Cgn via cre-mediated recombination in the germline. Consequently, the inserted Epstein-Barr sequence encoding LMP2A was placed under the control of the weak DQ52 promoter. (J:88472)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:88472 Casola S, et al., B cell receptor signal strength determines B cell fate. Nat Immunol. 2004 Mar;5(3):317-27
• All: 7 reference(s)