Tg(CD19-cre/ERT2)1Cgn
Transgene Detail

Summary

• Symbol: Tg(CD19-cre/ERT2)1Cgn
• Name: transgene insertion 1, University of Cologne
• MGI ID: MGI:3037896
• Synonyms: CD19-Cre, hCD19-CreERT2
• Transgene: Tg(CD19-cre/ERT2)1Cgn Location: unknown
• Alliance: Tg(CD19-cre/ERT2)1Cgn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(CD19-cre/ERT2)1Cgn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  CD19 (930)

  Cd19	(MGI:88319)

• Mutation details: This transgene expresses a tamoxifen-inducible form of cre recombinase from the human B cell-specific CD19 promoter. (J:88472)

Recombinase activity

Activity:	Tissue activity of this recombinase allele MGI has not yet included tissue activity data for this allele in any anatomical systems.
Driver:	CD19 (human) Summary of all recombinase alleles driven by CD19. Alliance human CD19 gene page

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Igh^tm5Cgn/Igh^tm5Cgn Tg(CD19-cre/ERT2)1Cgn/0	C.Cg-Igh^tm5Cgn Tg(CD19-cre/ERT2)1Cgn
cn2	Traf3ip2^tm1Lix/Traf3ip2^tm1.1Lix Tg(CD19-cre/ERT2)1Cgn/0	involves: 129/Sv * BALB/c
cn3	Igh^tm1.2Rsky/Igh^tm1.2Rsky Tg(CD19-cre/ERT2)1Cgn/?	involves: BALB/c
cn4	Ppp2r3c^tm1Imku/Ppp2r3c^tm1Imku Tg(CD19-cre/ERT2)1Cgn/?	involves: C57BL/6
cn5  Disease Model	Nbn^tm1Nus/Nbn^tm2Nus Tg(CD19-cre/ERT2)1Cgn/0	Not Specified
cn6	Cyld^tm1Awai/Cyld^tm1Awai Tg(CD19-cre/ERT2)1Cgn/?	Not Specified
cn7	Ikzf1^tm3Kge/Ikzf1^tm3Kge Tg(CD19-cre/ERT2)1Cgn/?	Not Specified

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5	cn6	cn7
show or hide all annotated terms
cellular				√	√		√
abnormal B cell apoptosis							√
decreased B cell proliferation				√	√
growth/size/body		√				√
enlarged spleen		√				√
hematopoietic system	√	√	√	√	√	√	√
enlarged spleen		√				√
abnormal B cell differentiation	√
decreased immature B cell number				√		√
decreased transitional stage B cell number				√
increased transitional stage B cell number				√
increased pro-B cell number	√			√
increased dendritic cell number		√
decreased B cell number				√
decreased mature B cell number				√
decreased B-1 B cell number						√
decreased B-1a cell number				√
decreased follicular B cell number				√
absent follicular B cells	√
absent marginal zone B cells	√
decreased pre-B cell number				√			√
absent pre-B cells							√
increased B cell number	√	√				√
increased T cell number				√
abnormal mature B cell morphology	√					√
small spleen				√
decreased spleen germinal center size				√
abnormal B cell physiology					√
abnormal B cell apoptosis							√
abnormal class switch recombination			√
abnormal B cell activation			√	√
decreased B cell proliferation				√	√
decreased IgG level					√
decreased IgG1 level					√
decreased IgG2a level					√
decreased IgG2b level					√
decreased IgG3 level					√
increased immunoglobulin level		√
immune system	√	√	√	√	√	√	√
enlarged spleen		√				√
abnormal B cell differentiation	√
decreased immature B cell number				√		√
decreased transitional stage B cell number				√
increased transitional stage B cell number				√
increased pro-B cell number	√			√
increased dendritic cell number		√
decreased B cell number				√
decreased mature B cell number				√
decreased B-1 B cell number						√
decreased B-1a cell number				√
decreased follicular B cell number				√
absent follicular B cells	√
absent marginal zone B cells	√
decreased pre-B cell number				√			√
absent pre-B cells							√
increased B cell number	√	√				√
increased T cell number				√
abnormal mature B cell morphology	√					√
small spleen				√
decreased spleen germinal center size				√
abnormal B cell physiology					√
abnormal B cell apoptosis							√
abnormal class switch recombination			√
abnormal B cell activation			√	√
decreased B cell proliferation				√	√
decreased IgG level					√
decreased IgG1 level					√
decreased IgG2a level					√
decreased IgG2b level					√
decreased IgG3 level					√
increased immunoglobulin level		√
abnormal Peyer's patch germinal center morphology	√
enlarged Peyer's patches						√
enlarged lymph nodes		√				√
abnormal humoral immune response				√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn5
Nijmegen breakage syndrome IDs Nijmegen breakage syndrome       DOID:7400 MESH:D049932 NCI:C4692 OMIM:251260 ORDO:647 UMLS_CUI:C0398791 Close	√

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88472 Casola S, et al., B cell receptor signal strength determines B cell fate. Nat Immunol. 2004 Mar;5(3):317-27
• All: 13 reference(s)