Egfr^Vel
Chemically induced Allele Detail

Summary

• Symbol: Egfr^Vel
• Name: epidermal growth factor receptor; velvet
• MGI ID: MGI:3037902
• Synonyms: Egfr^M1Btlr
• Gene: Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
• Alliance: Egfr^Vel page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: An A to G transition in the coding region causes the replacement of aspartic acid by glycine at position 833 (D833G). The mutation causes an alteration in the cytoplasmic tyrosine kinase domain structure and falls within a DFG motif known to be important for ATP coordination. (J:88776)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egfr Mutation: 87 strains or lines available

Notes

This allele contains the same point mutation as in Egfr^Wa5 in a different ENU screen and strain. Both alleles are considered antimorphs.

References

• Original: J:88776 Du X, et al., Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics. 2004 Jan;166(1):331-40
• All: 10 reference(s)