Hira^tm2Pjs
Targeted Allele Detail

Summary

• Symbol: Hira^tm2Pjs
• Name: histone cell cycle regulator; targeted mutation 2, Peter J Scambler
• MGI ID: MGI:3037947
• Synonyms: Hira^neoloxp
• Gene: Hira Location: Chr16:18695787-18789059 bp, + strand Genetic Position: Chr16, 11.69 cM, cytoband A-B1
• Alliance: Hira^tm2Pjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75491
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced 1.5 kb of sequences that includes the 3' end of exon 8. A loxP site was also inserted for use in future chomosome engineering experiments. (J:75491)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hira Mutation: 74 strains or lines available

References

• Original: J:75491 Roberts C, et al., Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol. 2002 Apr;22(7):2318-28
• All: 3 reference(s)