Tg(Krt2-6a-cre)1Ism
Transgene Detail

Summary

• Symbol: Tg(Krt2-6a-cre)1Ism
• Name: transgene insertion 1, Ian Smyth
• MGI ID: MGI:3038016
• Transgene: Tg(Krt2-6a-cre)1Ism Location: unknown
• Alliance: Tg(Krt2-6a-cre)1Ism page

Transgene origin

• Strain of Origin: CBA and C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Krt2-6a-cre)1Ism expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt2 (MGI:96699)

• Mutation details: The transgenic construct consisted of cDNA encoding cre recombinase adjoined to the mouse Krt2-6a promoter. Cre-mediated recombination was observed in the companion cell layer of hair follicles, a discrete cell population located between the inner and outer root sheaths. With retinoic acid treatment, the expression domain is expanded to the interfollicular basal and outer root sheath cells. (J:88795)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt2 (mouse) Summary of all recombinase alleles driven by Krt2. Comparative matrix view of recombinase activities Alliance mouse Krt2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88795 Smyth I, et al., Krt6a-Cre transgenic mice direct LoxP-mediated recombination to the companion cell layer of the hair follicle and following induction by retinoic acid to the interfollicular epidermis. J Invest Dermatol. 2004 Feb;122(1):232-4
• All: 3 reference(s)