Emx2^Pdo
Chemically induced Allele Detail

Summary

• Symbol: Emx2^Pdo
• Name: empty spiracles homeobox 2; pardon
• MGI ID: MGI:3038078
• Synonyms: Gena181, Pdo
• Gene: Emx2 Location: Chr19:59447122-59453789 bp, + strand Genetic Position: Chr19, 56.28 cM
• Alliance: Emx2^Pdo page

Mutation origin

• Strain of Origin: BALB/c
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A C-to-A transition mutation in position 623 of the coding sequence results in the phenotype in the pardon mouse. This mutation is predicted to cause a threonine to lysine substitution in the homeobox binding domain at position 208 of the encoded protein. (J:89093)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Emx2 Mutation: 24 strains or lines available

References

• Original: J:89093 Rhodes CR, et al., The homeobox gene Emx2 underlies middle ear and inner ear defects in the deaf mouse mutant pardon. J Neurocytol. 2003 Nov;32(9):1143-54
• All: 5 reference(s)