Il4/Il13^tm3Anjm
Targeted Allele Detail

Summary

• Symbol: Il4/Il13^tm3Anjm
• Name: interleukin 4; targeted mutation 3, Andrew NJ McKenzie
• MGI ID: MGI:3038244
• Synonyms: Il-4/13^-, Il-4^-Il-13^-
• Gene: Il4 Location: Chr11:53503287-53509492 bp, - strand Genetic Position: Chr11, 31.97 cM
• Alliance: Il4/Il13^tm3Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89095
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Homologous recombination results in the deletion of a 15 kb region from exon 3 of the Il13 locus to intron 3 of the Il4 locus. RT-PCR and ELISAs failed to detect any Il4 or Il13 mRNA in activated lymphocytes or protein in stimulated CD4⁺ T-cells. (J:89095)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il4 Mutation: 46 strains or lines available

References

• Original: J:89095 McKenzie GJ, et al., Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med. 1999 May 17;189(10):1565-72
• All: 73 reference(s)