F2r^tm1Pago
Targeted Allele Detail

Summary

• Symbol: F2r^tm1Pago
• Name: coagulation factor II thrombin receptor; targeted mutation 1, Patricia Andrade-Gordon
• MGI ID: MGI:3038377
• Synonyms: Par1^-, PAR-1^-, ThrR^-
• Gene: F2r Location: Chr13:95738311-95754995 bp, - strand Genetic Position: Chr13, 50.21 cM
• Alliance: F2r^tm1Pago page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38032
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 0.4 kb of genomic sequence encompassing the proximal promoter region and a 5' portion of exon 1 that included the start codon was replaced with a neo cassette inserted by homologous recombination. Normal transcript was undetected in homozygous mutant mice by Northern blot analysis of kidney tissue. (J:38032)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2r Mutation: 26 strains or lines available

References

• Original: J:38032 Darrow AL, et al., Biological consequences of thrombin receptor deficiency in mice. Thromb Haemost. 1996 Dec;76(6):860-6
• All: 29 reference(s)