Tg(CMV-Rpgr)1Tili
Transgene Detail

Summary

• Symbol: Tg(CMV-Rpgr)1Tili
• Name: transgene insertion 1, Tiansen Li
• MGI ID: MGI:3038604
• Transgene: Tg(CMV-Rpgr)1Tili Location: unknown
• Alliance: Tg(CMV-Rpgr)1Tili page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-Rpgr)1Tili expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rpgr (MGI:1344037)

• Mutation details: A mouse Rpgr ORF15 variant cDNA was inserted between the cytomegalovirus (CMV) enhancer promoter and the polyadenylation sequence of bovine growth hormone. The cDNA used in this construct is shortened by 654 base pairs in the purine-rich region of the ORF15 exon when compared to the published sequence of the 129/Sv mouse strain. This construct was used to generate transgenic mice by pronuclear injection. Transgene protein accumulates to a much lower level than the endogenous protein and migrated at a size smaller than the native protein. (J:87299)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:87299 Hong DH, et al., Dominant, gain-of-function mutant produced by truncation of RPGR. Invest Ophthalmol Vis Sci. 2004 Jan;45(1):36-41
• All: 1 reference(s)