Klf5^tm1Rng
Targeted Allele Detail

Summary

• Symbol: Klf5^tm1Rng
• Name: Kruppel-like transcription factor 5; targeted mutation 1, Ryozo Nagai
• MGI ID: MGI:3038696
• Synonyms: Klf5-
• Gene: Klf5 Location: Chr14:99536127-99550848 bp, + strand Genetic Position: Chr14, 49.43 cM, cytoband E2.1
• Alliance: Klf5^tm1Rng page

Pressure overload-induced cardiac hypertophy and fibrosis are reduced in Klf5^tm1Rng/Klf5⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78275
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' end of exon 2 and all of exon 3 were replaced with a neo cassette by homologous recombination. Western blot analysis showed decreased levels of protein in heterozygotes. (J:78275)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf5 Mutation: 37 strains or lines available

References

• Original: J:78275 Shindo T, et al., Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med. 2002 Aug;8(8):856-63
• All: 7 reference(s)