Slc27a1^tm1Jkk
Targeted Allele Detail

Summary

• Symbol: Slc27a1^tm1Jkk
• Name: solute carrier family 27 (fatty acid transporter), member 1; targeted mutation 1, Jason Kim
• MGI ID: MGI:3038701
• Synonyms: Fatp1^-, FATP1 KO
• Gene: Slc27a1 Location: Chr8:72021526-72039946 bp, + strand Genetic Position: Chr8, 34.43 cM, cytoband B3.3
• Alliance: Slc27a1^tm1Jkk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88657
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first exon was replaced with lacz by homologous recombination. Absence of Slc27a1 mRNA expression was confirmed with real time PCR. Microarray analysis indicated that there was no compensatory upregulation of other Slc27a in homozygotes (J:88657)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc27a1 Mutation: 32 strains or lines available

References

• Original: J:88657 Kim JK, et al., Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest. 2004 Mar;113(5):756-63
• All: 7 reference(s)