Psme3^tm1Jjm
Targeted Allele Detail

Summary

• Symbol: Psme3^tm1Jjm
• Name: proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki); targeted mutation 1, John J Monaco
• MGI ID: MGI:3038704
• Synonyms: PA28gamma^-, REGgamma^-
• Gene: Psme3 Location: Chr11:101207039-101214363 bp, + strand Genetic Position: Chr11, 64.67 cM
• Alliance: Psme3^tm1Jjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88626
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced exons 5-8 and produced a frameshift mutation in the downstream exons. Western blot analysis confirmed the absence of protein in homozygotes (J:88626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Psme3 Mutation: 17 strains or lines available

References

• Original: J:88626 Barton LF, et al., Immune defects in 28-kDa proteasome activator gamma-deficient mice. J Immunol. 2004 Mar 15;172(6):3948-54
• All: 14 reference(s)