Psme3^tm1Tchi
Targeted Allele Detail

Summary

• Symbol: Psme3^tm1Tchi
• Name: proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki); targeted mutation 1, Tomoki Chiba
• MGI ID: MGI:3038739
• Synonyms: PA28gamma^-
• Gene: Psme3 Location: Chr11:101207039-101214363 bp, + strand Genetic Position: Chr11, 64.67 cM
• Alliance: Psme3^tm1Tchi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89182
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced approximately 3kb including exons 2 - 8. Northern and Western blot analysis confirmed the absence of RNA and protein in homozygotes (J:89182)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Psme3 Mutation: 17 strains or lines available

References

• Original: J:89182 Murata S, et al., Growth retardation in mice lacking the proteasome activator PA28gamma. J Biol Chem. 1999 Dec 31;274(53):38211-5
• All: 5 reference(s)