Cfb^tm1Pkna
Targeted Allele Detail

Summary

• Symbol: Cfb^tm1Pkna
• Name: complement factor B; targeted mutation 1, Marcela Pekna
• MGI ID: MGI:3038803
• Synonyms: Cfb^tm1Pkny, fB^-
• Gene: Cfb Location: Chr17:35075350-35081492 bp, - strand Genetic Position: Chr17, 18.41 cM
• Alliance: Cfb^tm1Pkna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47578
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 and exons 4-9 were replaced by a neomycin cassette via homologous recombination. These exons contained sequence coding for the entire Ba fragment and a large part of the first serine protease domain. Transcripts from homozygous mutant liver were shorter than that of wild-type mice, putatively the truncated, non-functional transcript from the mutant allele. (J:47578)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfb Mutation: 29 strains or lines available

References

• Original: J:47578 Pekna M, et al., Mice deficient for the complement factor B develop and reproduce normally. Scand J Immunol. 1998 Apr;47(4):375-80
• All: 9 reference(s)