Vangl2^ska17
Chemically induced Allele Detail

Summary

• Symbol: Vangl2^ska17
• Name: VANGL planar cell polarity 2; skeletal/axial 17
• MGI ID: MGI:3038827
• Synonyms: Lp^m2Jus, ska^m17Jus, Vangl2^R259L
• Gene: Vangl2 Location: Chr1:171828527-171856011 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Vangl2^ska17 page

Mutation origin

• Strain of Origin: C57BL/6Brd-Tyr^c-Brd
• Project Collection: Mutagenesis for Dev. Defects

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A missense mutation that alters a G to a T at position 776 in the cDNA which changes arginine 259 to leucine was induced by ENU treatment. Western blot analysis indicated protein levels in the brains of homozygous mice at E16.5 were about 90% that of wild-type littermates. (J:169664)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vangl2 Mutation: 34 strains or lines available

References

• Original: J:89098 The Mouse Genome Project at The Baylor College of Medicine, Heritable mouse mutants from the Mouse Mutagenesis for Developmental Defects Program. MGI Direct Data Submission. 2004-5
• All: 2 reference(s)