Sigirr^tm1Mant
Targeted Allele Detail

Summary

• Symbol: Sigirr^tm1Mant
• Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; targeted mutation 1, Alberto Mantovani
• MGI ID: MGI:3038878
• Synonyms: Tir8^-, TIR8^-
• Gene: Sigirr Location: Chr7:140671088-140680485 bp, - strand Genetic Position: Chr7, 86.35 cM
• Alliance: Sigirr^tm1Mant page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88907
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination was used to insert IRES-LacZ followed by a PGK-neo cassette into exon 2, 51 bp 3' of the first ATG. No transcript was detected in mutant mice from the kidney or colon. (J:88907)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sigirr Mutation: 29 strains or lines available

References

• Original: J:88907 Garlanda C, et al., Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3522-6
• All: 19 reference(s)