Calcr^tm1Dgal
Targeted Allele Detail

Summary

• Symbol: Calcr^tm1Dgal
• Name: calcitonin receptor; targeted mutation 1, D L Galson
• MGI ID: MGI:3038975
• Synonyms: Calcr^-, CTR -
• Gene: Calcr Location: Chr6:3685680-3764714 bp, - strand Genetic Position: Chr6, 1.81 cM
• Alliance: Calcr^tm1Dgal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92983
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination was used to replace exons 6 and 7 with a neomycin cassette in the reverse orientation to the endogenous allele. Real time PCR demonstrated that expression of heterozygous osteoclasts was decreased compared with that of wild-type. (J:92983)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calcr Mutation: 59 strains or lines available

References

• Original: J:92983 Laplace C, et al., (Homozygous deletion of the murine calcitonin receptor gene is an embryonic lethal). Abstracts of the 24th Annual Meeting of the American Society for Bone and Mineral Research. San Antonio, Texas, USA. September 20-24, 2002. J Bone Miner Res. 2002;17 Suppl 1:S125-541 (S143)
• All: 2 reference(s)