Ccna1^tm1Coll
Targeted Allele Detail

Summary

• Symbol: Ccna1^tm1Coll
• Name: cyclin A1; targeted mutation 1, William H Colledge
• MGI ID: MGI:3038977
• Synonyms: Ccna1^tm1Col
• Gene: Ccna1 Location: Chr3:54952890-54962922 bp, - strand Genetic Position: Chr3, 26.52 cM
• Alliance: Ccna1^tm1Coll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89030
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LacZ is fused immediately after the initiator methionine and all of the coding exons are deleted. RT-PCR and Western blot analysis confirmed the absence of RNA and protein expression in homozygotes. Beta-galactosidase is expressed from this allele. (J:89030)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccna1 Mutation: 28 strains or lines available

References

• Original: J:89030 van der Meer T, et al., Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice. Reproduction. 2004 Apr;127(4):503-11
• All: 3 reference(s)