Foxo3^{Gt(VICTR20)1Kca}
Gene trapped Allele Detail

Summary

• Symbol: Foxo3^{Gt(VICTR20)1Kca}
• Name: forkhead box O3; gene trap 1, Karen C Arden
• MGI ID: MGI:3038979
• Synonyms: Foxo3a^-, Foxo3^Kca
• Gene: Foxo3 Location: Chr10:42057841-42152691 bp, - strand Genetic Position: Chr10, 22.79 cM
• Alliance: Foxo3^{Gt(VICTR20)1Kca} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88638
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A retroviral gene trap vector was inserted into intron 1. Western blot analysis confirmed the absence of protein expression in homozygotes (J:88638)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo3 Mutation: 51 strains or lines available

References

• Original: J:88638 Hosaka T, et al., Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci U S A. 2004 Apr 2;101(9):2975-80
• All: 8 reference(s)