Fgl2^tm1Stsm
Targeted Allele Detail

Summary

• Symbol: Fgl2^tm1Stsm
• Name: fibrinogen-like protein 2; targeted mutation 1, Stephen T Smiley
• MGI ID: MGI:3038987
• Gene: Fgl2 Location: Chr5:21577671-21583384 bp, + strand Genetic Position: Chr5, 9.83 cM
• Alliance: Fgl2^tm1Stsm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88648
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced both exons via homologous recombination. Western blot analysis confirmed the absence of secreted protein expression in stimulated macrophages from homozygotes (J:88648)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgl2 Mutation: 27 strains or lines available

References

• Original: J:88648 Hancock WW, et al., Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3005-10
• All: 3 reference(s)