Nfat5^tm1Rao
Targeted Allele Detail

Summary

• Symbol: Nfat5^tm1Rao
• Name: nuclear factor of activated T cells 5; targeted mutation 1, Anjana Rao
• MGI ID: MGI:3038988
• Gene: Nfat5 Location: Chr8:108020102-108106149 bp, + strand Genetic Position: Chr8, 53.93 cM, cytoband D2
• Alliance: Nfat5^tm1Rao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88636
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An inverted neo cassette replaced the Rel-DNA binding domain within exon 6 via homologous recombination. Western blot analysis confirmed the absence of protein expression in lymphocytes from homozygotes (J:88636)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfat5 Mutation: 67 strains or lines available

References

• Original: J:88636 Lopez-Rodriguez C, et al., Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2392-7
• All: 9 reference(s)