Tg(MMTV-Erbb2)1Pv
Transgene Detail

Summary

• Symbol: Tg(MMTV-Erbb2)1Pv
• Name: transgene insertion 1, Paolo Vezzoni
• MGI ID: MGI:3039042
• Synonyms: Her2/neu, HER-2/neu, NeuT
• Transgene: Tg(MMTV-Erbb2)1Pv Location: unknown
• Alliance: Tg(MMTV-Erbb2)1Pv page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F1 x CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Erbb2)1Pv expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

• Mutation details: This transgene contains the mouse mammary tumor virus promoter and a 4.6 kb cDNA from the rat avian erythroblastosis B2 oncogene. The activated form of the gene is used in this construct, which differs from the wild-type allele by a point mutation, Val664Glu. (J:72082)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Erbb2)1Pv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:72082 Lucchini F, et al., Early and multifocal tumors in breast, salivary, harderian and epididymal tissues developed in MMTY-Neu transgenic mice. Cancer Lett. 1992 Jul 10;64(3):203-9
• All: 48 reference(s)