Cyp26b1^tm1Hmd
Targeted Allele Detail

Summary

• Symbol: Cyp26b1^tm1Hmd
• Name: cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 1, Hiroshi Hamada
• MGI ID: MGI:3039046
• Synonyms: Cyp26b1^-, Cyp26b1^tm1Hh
• Gene: Cyp26b1 Location: Chr6:84548396-84570890 bp, - strand Genetic Position: Chr6, 36.45 cM
• Alliance: Cyp26b1^tm1Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89029
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination was used to replace exons 3-5 and part of 6 with a PGK-puro cassette. These exons encode the heme-binding, steroid-binding and oxygen-binding domains. (J:89029)

Expression

In Mice Carrying this Mutation:	388 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp26b1 Mutation: 35 strains or lines available

References

• Original: J:89029 Yashiro K, et al., Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell. 2004 Mar;6(3):411-22
• All: 19 reference(s)