Llgl1^tm1.1Vv
Targeted Allele Detail

Summary

• Symbol: Llgl1^tm1.1Vv
• Name: LLGL1 scribble cell polarity complex component; targeted mutation 1.1, Valeri Vasioukhin
• MGI ID: MGI:3039269
• Synonyms: Lgl1^-
• Gene: Llgl1 Location: Chr11:60590549-60605012 bp, + strand Genetic Position: Chr11, 37.81 cM
• Alliance: Llgl1^tm1.1Vv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89028
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed exon in Llglh^tm1Vv was removed via cre-mediated recombination, leaving a single LoxP site in its place. The deletion resulted in a frame shift in translation of the protein, which is predicted to disrupt translation after the first 27 amino acids that do not encode any known domains. Western blot analysis from mutants showed no protein was present. (J:89028)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Llgl1 Mutation: 63 strains or lines available

References

• Original: J:89028 Klezovitch O, et al., Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev. 2004 Mar 1;18(5):559-71
• All: 6 reference(s)