Tg(Alb1-Ren)2Unc
Transgene Detail

Summary

• Symbol: Tg(Alb1-Ren)2Unc
• Name: transgene insertion 2, University of North Carolina
• MGI ID: MGI:3039271
• Synonyms: RenTgMK, Tg(Alb1-Ren)1Smi
• Transgene: Tg(Alb1-Ren)2Unc Location: unknown
• Alliance: Tg(Alb1-Ren)2Unc page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:89252
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb1-Ren)2Unc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ren1 (MGI:97898)

• Mutation details: A single copy of a transgene consisting of a liver specific albumin promoter, a 20 bp insert in the 5' UTR to increase length, a synthetic mouse renin cDNA, and a rabbit beta-globin 3' UTR was inserted into the apolipoprotein locus between the Apoa1 and Apoc3 genes. (J:89252)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:89252 Caron KM, et al., A genetically clamped renin transgene for the induction of hypertension. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8248-52
• All: 10 reference(s)