Tg(Apoe-Lep)1Kry
Transgene Detail

Summary

• Symbol: Tg(Apoe-Lep)1Kry
• Name: transgene insertion 1, Gerard Karsenty
• MGI ID: MGI:3039272
• Synonyms: ApoE-leprin
• Transgene: Tg(Apoe-Lep)1Kry Location: unknown
• Alliance: Tg(Apoe-Lep)1Kry page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Apoe-Lep)1Kry expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lep (MGI:104663)

• Mutation details: Mouse Lep cDNA was cloned 3' of the liver specific Apoe promoter and 5' of liver specific enhancer sequence. Serum Lep expression is 200- to 300-fold higher than in wild-type mice. (J:88655)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88655 Elefteriou F, et al., Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3258-63
• All: 1 reference(s)