Sell^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Sell^tm1Flv
• Name: selectin, lymphocyte; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3039283
• Synonyms: CD62L^-
• Gene: Sell Location: Chr1:163889556-163908354 bp, + strand Genetic Position: Chr1, 71.37 cM
• Alliance: Sell^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89253
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced 5.5 kb encoding the Sell domain via homologous recombination. Flow cytometry confirmed the absence of protein expression in peripheral blood leukocytes. (J:89253)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sell Mutation: 42 strains or lines available

References

• Original: J:89253 Xu J, et al., Impaired primary T cell responses in L-selectin-deficient mice. J Exp Med. 1996 Feb 1;183(2):589-98
• All: 10 reference(s)