Efnb1^tm1.1Sor
Targeted Allele Detail

Summary

• Symbol: Efnb1^tm1.1Sor
• Name: ephrin B1; targeted mutation 1.1, Philippe Soriano
• MGI ID: MGI:3039290
• Synonyms: ephrin-B1^null
• Gene: Efnb1 Location: ChrX:98179736-98192597 bp, + strand Genetic Position: ChrX, 43.22 cM, cytoband D
• Alliance: Efnb1^tm1.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89008
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removes the floxed exons 2-5 in Ephb1^tm1Sor, leaving a PGK-neo-bpA cassette flanked by FRT sites. Western blot of embryo lysates confirmed absence of the endogenous protein. (J:89008, J:143845)

Disease models

Expression

In Mice Carrying this Mutation:	60 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb1 Mutation: 15 strains or lines available

References

• Original: J:89008 Davy A, et al., Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev. 2004 Mar 1;18(5):572-83
• All: 13 reference(s)