Tg(Arr2/Pbsn-FGFR1K656E)1Wmck
Transgene Detail

Summary

• Symbol: Tg(Arr2/Pbsn-FGFR1K656E)1Wmck
• Name: transgene insertion 1, Wallace L McKeenan
• MGI ID: MGI:3039371
• Synonyms: ARR2PBi-caFGFR1, Tg(Arr2/Pbsn-FGFR1K656E)W
• Transgene: Tg(Arr2/Pbsn-FGFR1K656E)1Wmck Location: unknown
• Alliance: Tg(Arr2/Pbsn-FGFR1K656E)1Wmck page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Arr2/Pbsn-FGFR1K656E)1Wmck expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGFR1 (2260)

  Fgfr1

  (MGI:95522)

• Mutation details: The human two immunoglobulin-loop isoform of FGFR1 bearing the K656E mutation and an artificial FLAG epitope was inserted downstream of the ARR2PB composite promoter that consists of a minimal probasin promoter that was modified to contain two androgen response elements. RT-PCR analysis showed that transgene expression is limited to the prostate gland. (J:87067)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Arr2/Pbsn-FGFR1K656E)1Wmck

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:87067 Jin C, et al., Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate. Cancer Res. 2003 Dec 15;63(24):8784-90
• All: 1 reference(s)